Immunotherapy Markers

 

Immunotherapy Markers



PD-L1 + p40

• Immune checkpoint marker in tumor immunotherapy 1,2

• PD-L1 stains tumor membranes (brown) 1,2

• p40 stains tumor nuclei (blue) 1,2

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PD-L1 + TTF-1

• Immune checkpoint marker in tumor immunotherapy 1,2

• PD-L1 stains tumor membranes (brown) 1,2

• TTF-1 stains tumor nuclei (blue) 1,2

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PD-L1 + p40 + CD8

• PD-L1 stains tumor membrane (brown) 3

• p40 stains tumor cell nuclei (blue) 3

• CD8+ T cells are stained red and scattered within tumor cells 3

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CD8 + PD-1 + MART-1

• MART-1 & Tyrosinase (mask) stains melanoma cells (green) 3

• Some TILS are CD8+ T-cells (red) 3

• Some CD8+ T cells co-express PD-1 (black, arrow) 3

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References:
1. Brahmer J, et al. NEJM 2015;373:123-35
2. Melosky, B, et al. J Clin Oncol 2016;14:1676-88
3. Kakavand, H, et al. Pathology 2016;48:194-202