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Immunotherapy Markers

PD-L1 + p40
• Immune checkpoint marker in tumor immunotherapy 1,2
• PD-L1 stains tumor membranes (brown) 1,2
• p40 stains tumor nuclei (blue) 1,2
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Buy p40
PD-L1 + TTF-1
• Immune checkpoint marker in tumor immunotherapy 1,2
• PD-L1 stains tumor membranes (brown) 1,2
• TTF-1 stains tumor nuclei (blue) 1,2
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Buy TTF-1
PD-L1 + p40 + CD8
• PD-L1 stains tumor membrane (brown) 3
• p40 stains tumor cell nuclei (blue) 3
• CD8+ T cells are stained red and scattered within tumor cells 3
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Buy p40
Buy CD8
CD8 + PD-1 + MART-1
• MART-1 & Tyrosinase (mask) stains melanoma cells (green) 3
• Some TILS are CD8+ T-cells (red) 3
• Some CD8+ T cells co-express PD-1 (black, arrow) 3
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Buy PD-1
Buy MART-1
References:
1. Brahmer J, et al. NEJM 2015;373:123-35
2. Melosky, B, et al. J Clin Oncol 2016;14:1676-88
3. Kakavand, H, et al. Pathology 2016;48:194-202