GLUT-1
Glucose transporter 1, also known as GLUT-1 or SLC2A1 is a protein in humans encoded by the SLC2A1 gene. GLUT-1 facilitates the transport of glucose across the plasma membranes of mammalian cells. GLUT1 is responsible for the low-level of basal glucose uptake required to sustain respiration in all cells. Several glucose transporter protein isoforms have been identified and shown to function in response to insulin and IGF-1 induced signaling. Immunohistochemical studies have shown GLUT-1 expression in many human tissues including those of the colon, lung, stomach, esophagus and breast. A high expression of GLUT-1 immunoreactivity in cancer has been associated with aggressive behavior and shorter disease free survival. Hypoxia in cancer has a significant impact on clinical outcome and surrogate markers for tumor hypoxia such as GLUT-1 and HIF-1alpha. Both markers have shown prognostic significance for patient outcome.
| Ordering Information |
Catalog Number |
Volume |
| Concentrate |
CM 408 |
A, C |
| Predilute |
PM 408 |
AA |
| intelliPATH™ |
N/A |
N/A |
| VP Echelon |
N/A |
N/A |
| A / AK = 0.1 ml |
B / BK = 0.5 ml |
C / CK = 1.0 ml |
G5 = 5.0 ml |
AA = 6.0 ml |
H / G25 = 25 ml |
L = 100 ml |
