CD31

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CD31 recognizes a 100kDA glycoprotein in endothelial cells and 130kD in platelets. It reacts weakly with mantle zone B-cells, peripheral T-cells, and neutrophils. CD31 can detect vascular endothelium associated antigen and has been used as a marker for benign and malignant human vascular disorders, myeloid leukemia infiltrates and megakaryocytes in normal bone marrow. When compared to Factor VIII and CD34 antibodies, studies have shown CD31 to be a superior marker for angiogenesis. CD31 has been used to measure angiogenesis, which reportedly predicts tumor recurrence. CD31 used in a panel with CD34 and Factor VIII has also been used to mark Kaposi’s sarcoma and angiosarcomas. Other studies have also indicated that CD31 and CD34 can be used as markers for myeloid progenitor cells that recognize different subsets of myeloid leukemia infiltrates (granular sarcomas).

Intended Use

IVD

Species Reactivity

Human

Source

Mouse Monoclonal

Clone

BC2

Isotype

IgG1/kappa

Antigen

CD31

Localization

Cytoplasmic/membrane

Positive Control

Tonsil, angiosarcoma, or colon cancer

1. Govender D, Harilal P, Dada M, Chetty R. CD31 (JC70) expression in plasma cells: an immunohistochemical analysis of reactive and neoplastic plasma cells. J Clin Pathol 1997 Jun;50(6):490-3.
2. Rongioletti F et al. Tumor vascularity as a prognostic indicator in intermediatethickness (0.76-4 mm) cutaneous melanoma. A quantitative assay. Am J Dermatopathol 1996 Oct;18(5):474-7.
3. Engel CJ, Bennett ST et al.. Tumor angiogenesis predicts recurrence in invasive colorectal cancer when controlled for Dukes staging. Am J Surg Pathol 1996 Oct;20 (10):1260-5.
4. Russell Jones R et al. Staining for CD31 and CD34 in Kaposi sarcoma. Virchows Arch 1996 Jul;428(4-5):217-21.
5. Poblet E et al. Different immunoreactivity of endothelial markers in well and poorly differentiated areas of angiosarcomas. J Clin Pathol 1995 Nov;48(11):1011-6.
6. Hudock J, Chatten J, Miettinen M. Immunohistochemical evaluation of myeloid leukemia infiltrates (granulocytic sarcomas) in formaldehyde-fixed, paraffin-embedded tissue. Am J Clin Pathol. 1994 Jul;102(1):55-60.
7. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
8. National Committee for Clinical Laboratory Standards(NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood an

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