MOC-31
MOC-31, also known as Epithelial specific Antigen/Ep-CAM, consists of two 34 and 39 kDa glycoproteins. These glycoproteins are located on the cell membrane surface and in the cytoplasm of virtually all epithelial cells with the exception of most squamous epithelia, hepatocytes, renal proximal tubular cells, gastric parietal cells and myoepithelial cells. MOC-31 is used in a panel of antibodies as a negative marker for mesothelioma; and a negative stain for MOC-31 has been shown to exclude lung adenocarcinoma. MOC-31 is useful in differentiating tumors of unknown origin in liver cancers and distinguishing cholangiocarcinoma (+) from hepatocellular carcinomas (-). MOC-31 may be advantageous in the demonstration of epithelial cell differentiation in cases where anti-cytokeratins are not clearly positive or in cases where a false positivity for cytokeratin cannot be excluded, such as in submesothelial cells.
| Ordering Information |
Catalog Number |
Volume |
| Concentrate |
CM 403 |
A, C |
| Predilute |
PM 403 |
AA |
| intelliPATH™ |
IP 403 |
G10 |
| VP Echelon |
N/A |
N/A |
| A / AK = 0.1 ml |
B / BK = 0.5 ml |
C / CK = 1.0 ml |
G5 = 5.0 ml |
AA = 6.0 ml |
H / G25 = 25 ml |
L = 100 ml |
