CD19
CD19 recognizes a 95kD cell surface glycoprotein, which is expressed by cells of the B-cell lineage and follicular dendritic cells. CD19 is a co-receptor of CD21and is an important signal transduction molecule which is involved in the regulation of Blymphocyte development, activation and differentiation. Among the B-cell genes that are present in early B-cell development and are upregulated by Pax-5 are CD19 and CD79a. CD19 is found in Pre B cells, B cells (considered a pan B-cell antigen); first B-cell antigen after HLA-DR and follicular dendritic cells. CD19 is absent in plasma cells, most T-cell lymphomas and in lymphocyte predomoninant Hodgkin’s. It has been observed in lymphomas and leukemias but often weak/negative in follicular lymphoma or diffuse large B-cell lymphoma. CD19 is well-suited for formalin-fixed paraffin-embedded tissues, flow cytometry and western blotting techniques. CD19 may provide useful diagnostic information for the study of B-lymphoproliferative disorders.
| Ordering Information |
Catalog Number |
Volume |
| Concentrate |
CM 310 |
A, C |
| Predilute |
PM 310 |
AA |
| intelliPATH™ |
N/A |
N/A |
| VP Echelon |
N/A |
N/A |
| A / AK = 0.1 ml |
B / BK = 0.5 ml |
C / CK = 1.0 ml |
G5 = 5.0 ml |
AA = 6.0 ml |
H / G25 = 25 ml |
L = 100 ml |
