Uroplakin II + Uroplakin III

Product Description

Uroplakin II (UPII) and Uroplakin III (UPIII) are 15 kDa and 47 kDa proteins, respectively, that are key components of urothelial plaques, which enhance the permeability barrier of the urothelium.¹⁵ UPII and UPIII may be found in the urothelial surface membrane of human renal pelvis, ureter, bladder and urethra. UPII and UPIII have also been identified as sensitive and highly specific markers for urothelial carcinoma.^16-19

Specifications

1. Wu XR, et al. Uroplakins in urothelial biology, function, and disease. Kidney Int.
2009 Jun; 75(11):1153-65.
2. Moll R, et al. Uroplakins, specific membrane proteins of urothelial umbrella cells, as
histological markers of metastatic transitional cell carcinomas. Am J Pathol. 1995 Nov;
147(5):1383-97.
3. Kaufmann O, Volmerig J, Dietel M. Uroplakin III is a highly specific and
moderately sensitive immunohistochemical marker for primary and metastatic
urothelial carcinomas. Am J Clin Pathol. 2000 May; 113(5):683-7.
4. Olsburgh J, et al. Uroplakin gene expression in normal human tissues and locally
advanced bladder cancer. J Pathol. 2003 Jan; 199(1):41-9.
5. Huang HY, et al. Persistent uroplakin expression in advanced urothelial carcinomas:
implications in urothelial tumor progression and clinical outcome. Hum Pathol. 2007
Nov; 38(11):1703-13.
6. Hoang LL, et al. A newly developed Uroplakin II antibody with increased sensitivity
in urothelial carcinoma of the bladder. Arch Pathol Lab Med. 2013; in press.
7. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22,
Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove
Azide Salts.”
8. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory
Workers from Occupationally Acquired Infections; Approved Guideline-Fourth
Edition CLSI document M29-A4 Wayne, PA 2014.