SOX11 (M)
$266.00 – $871.00
Description
Product Description
The SOX11 (M) [SOX11-C1] antibody is a mouse monoclonal antibody developed for the detection of SOX11 (SRY-box transcription factor 11), a member of the SOX family of transcription factors involved in embryonic development and cellular differentiation.15 SOX11 is strongly expressed in most cases of mantle cell lymphoma (MCL), including those that are cyclin D1-negative, making it a valuable diagnostic marker in challenging MCL cases where the t(11;14) translocation or cyclin D1 overexpression is absent. The SOX11-C1 clone demonstrates strong nuclear staining and has shown improved sensitivity and specificity compared to earlier antibodies for SOX11 detection in MCL.16-17 In addition to its diagnostic utility in MCL, SOX11 expression has also been associated with a favorable prognosis in glioblastoma. The immunohistochemical (IHC) detection of SOX11 using the SOX11 (M) [SOX11- C1] antibody may aid in the evaluation of hematopoietic and central nervous system tumors.18-19
Specifications
Specifications
| Weight | .4 lbs |
|---|---|
| Dimensions | 1 × 1 × 1 in |
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Datasheets & SDS
| Download CE Marked IVD Datasheet |
| Download IVD Datasheet Without CE Mark |
| Download RUO Datasheet |
| Download SDS Sheet |
Browse more documents for this product (IFUs, datasheets, translations, SDS, and more).
References
1. Pusch C, et al. The SOX10/Sox10 gene from human and mouse: sequence, expression, and transactivation by the encoded HMG domain transcription factor. Hum Genet. 1998 Aug; 103(2):115-23.
2. Soldini D, et al. Assessment of SOX11 expression in routine lymphoma tissue sections: characterization of new monoclonal antibodies for diagnosis of mantle cell lymphoma. Am J Surg Pathol. 2014 Jan; 38(1):86-93.
3. Chen YH, et al. Nuclear expression of sox11 is highly associated with mantle cell lymphoma but is independent of t(11;14)(q13;q32) in non-mantle cell B-cell neoplasms. Mod Pathol. 2010 Jan; 23(1):105-12.
4. Nordström L, et al. Expanded clinical and experimental use of SOX11 – using a monoclonal antibody. BMC Cancer. 2012 Jun 27;12:269.
5. Korkolopoulou P, et al. Sox11 expression in astrocytic gliomas: correlation with nestin/c-Met/IDH1-R132H expression phenotypes, p-Stat-3 and survival. Br J Cancer. 2013 May 28;108(10):2142-52.
6. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
7. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved guideline-Third Edition CLSI document M29-A3 Wayne, PA 2005.
