The MYC (8q24) Break Apart FISH probe is designed to detect chromosomal rearrangements involving the MYC gene on Chromosome 8q24. The MYC gene belongs to a family of transcription factors and under normal conditions it controls cell cycle progression1. However in multiple cancer indications, MYC is considered a Proto-oncogene1. MYC gene deregulation is identified in multiple malignancies such as Burkitt’s lymphoma, diffuse large B-cell lymphoma, and B-cell lymphoma2. MYC gene amplifications, rearrangements, and/or point mutations are considered the underlining mechanisms that induce MYC gene deregulation1. Specifically, a MYC gene rearrangement is considered a prognostic marker in several cancer subtypes. MYC gene rearrangements can be identified using conventional cytogenetic techniques such as fluorescence in situ hybridization (FISH).