MSH6 [BC19]

Product Description

MSH6 functions, along with MSH2, MLH1, and PMS2, as part of the DNA mismatch repair (MMR) pathway, are utilized by normal proliferating cells to repair mutations that may occur during DNA replication.¹⁶ MSH6 is a heterodimer of MSH2 and binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes a single-based mispair insertion/deletion loop.^15,16 Antibodies to MSH6 may be a useful aid for classification of tumors of the gastrointestinal tract, including colorectal cancers.¹⁶

Specifications

1. Renkonen E, et al. Altered expression of MLH1, MSH2, and MSH6 in predisposition to hereditary nonpolyposis colorectal cancer. J Clin Oncol. 2003; 21:3629-37.
2. Graham RP, et al. Heterogenous MSH6 loss is a result of microsatellite instability within MSH6 and occurs in sporadic and hereditary colorectal and endometrial carcinomas. Am J Surg Pathol. 2015; 39:1370-6.
3. Lee LH, et al. Patterns and prognostic relevance of PD-1 and PD-L1 expression in colorectal carcinoma. Mod Pathol. 2016; 29:1333-42.
4. Le DI, et al. PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med. 2015;372:2509-20.
5. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
6. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory Workers from Occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.