MSH2

Product Description

MSH2 is a 100 kDa nuclear antigen and encodes a protein of 934 amino acids.¹ MSH2 functions, along with MLH1, PMS2, and MSH6, as part of the DNA mismatch repair (MMR) pathway, are utilized by normal proliferating cells to repair mutations that may occur during DNA replication. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMS2. Antibodies to MSH2 may be a useful aid for classification of tumors of the gastrointestinal tract, including colorectal cancers.^1,2

Specifications

1. Sordet C, Goetz J, Sibilia J. Contribution of autoantibodies to the diagnosis and nosology of inflammatory muscle disease. Joint Bone Spine. 2006 Dec;73(6):646-54.
2. Peltomäki P. Role of DNA mismatch repair defects in the pathogenesis of human cancer. J Clin Oncol 2003,21:1174-9
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