MET (7q31) Orange + Copy Control 7 Green

Product Description

The MET (7q31) Orange + Copy Control 7 Green FISH probe is design to detect the MET gene region located on 7q31. MET (7q31) is a protooncogene that encodes a transmembrane tyrosine kinase receptor, and regulates cellular pathways responsible for cell proliferation1. Aberrant activation of MET (7q31) signaling occurs in a subset of cancers such as non-small-cell lung cancer and gastric cancer (1,2). MET (7q31) gene amplification in cancer has been associated with poor prognosis and has been detected in malignant tumors using fluorescence in situ hybridization (1,3).

Specifications

1.Cappuzzo, F., et al. “Increased MET Gene Copy Number Negatively Affects Survival of Surgically Resected Non-Small-Cell Lung Cancer Patients.” Journal of Clinical Oncology (2009): 1667-674.
2. Peng, Zhi, et al. “Prognostic Significance of MET Amplification and Expression in Gastric Cancer: A Systematic Review with Meta-Analysis.” PLoS ONE (2014): E84502.
3. Kawakami, Hisato, et al. “Targeting MET Amplification as a New Oncogenic Driver.” Cancers 6 (2014): 1540-552.
4. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.