The ALK (2p23.2) Break Apart FISH Probe is designed to detect the rearrangement of the ALK gene located on 2p23. The ALK gene can fuse with one of 20 known ALK gene rearrangement partners, the most common being t(2;5)(p23;q35)1.The resultant fusion proteins generated from ALK gene rearrangement plays a vital role in driving the pathogenesis of several different types of cancer, such as nonsmall lung cancer and anaplastic large cell lymphoma2.
1. UCSC Genome Browser on Human Feb. 2009 (GRCh37/hg19) Assembly: Human Gene ALK (uc002rmy.2) Description and Page Index.
2. Varella-Garcia M, Aisner DL. ALK Rearrangement in Non Small Cell Lung Carcinoma. Assoc. for Mol. Path.: Molecular Reviews in Solid Tumors, (Nov 2010)
3. Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 2007;448:561-566.
4. Amin HM, et al. Selective inhibition of STAT3 induces apoptosis and G1 cell cycle arrest in ALK-positive anaplastic large cell lymphoma. Oncogene 2004;23:54326-5434.
5. Solomon B, Varella-Garcia M, Camidge DR.ALK Gene Rearrangements: A New Therapeutic Target in a Molecularly Defined Subset of Non-small Cell Lung Cancer. Journal of Thoracic Oncology 2009. Vol 4:12:1450-1454.