IGH (14q32) Break Apart Orange/Green

Product Description

The IGH (14q32) Break Apart probe is designed to detect chromosomal rearrangements involving the immunoglobulin heavy chain (IGH) gene on chromosome 14q32. To date, 43 different IGH chromosomal gene arrangement pairings have been identified (3). The majority of these chromosomal rearrangements can be detected using conventional cytogenetic techniques such as, fluorescence in situ hybridization (FISH). Multiple Myeloma (MM) and Non-Hodgkins lymphomas (NHL) are both characterized by recurrent chromosomal gene arrangements involving the IGH gene (1,2). The incidence of IGH gene rearrangements have been linked to MM pathogenesis and contribute to both the clinical and morphological features associated with NHL subtypes (1,2).

Specifications

1. Sawyer, Jeffrey R. “The Prognostic Significance of Cytogenetics and Molecular Profiling in Multiple Myeloma.” Cancer Genetics (2011): 3-12.
2. Bernicot, I., N. Douet-Guilbert, M.-J. Le Bris, A. Herry, F. Morel, and M. De Braekeleer. “Molecular Cytogenetics of IGH Rearrangements in Non-Hodgkin B-cell Lymphoma.” Cytogenetic and Genome Research (2007): 345-52.
3. “IGH (Immunoglobulin Heavy).” IGH (Immunoglobulin Heavy). Atlas of Genetics and Cytogenetics in Oncology and Haematology. Web. .
4. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.