Human chorionic gonadotropin antibody (hCG) is a glycoprotein hormone synthesized in syncytiotrophoblastic cells of placenta and in certain trophoblastic tumors. The hormone-specific beta chains have molecular weights of 14 kDa and 17 kDa, respectively. It is believed that the C-terminal region of then CG-beta subunit plays a role in the intracellular behavior of the heterodimer. This antibody labels the cytoplasm of syncytiotrophoblastic cells and their tumors, as well as germ cell tumors of the ovaries, testes and extragonadal sites.
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