GATA-3

Product Description

GATA-3 (GATA binding protein 3) is a member of the GATA family of transcription factors. This 50 kDa nuclear protein regulates the development and is expressed in specific cell types within a variety of tissues.^1,2 GATA-3 is a zinc finger transcription factor and plays an important role in promoting and directing cell proliferation, development, and differentiation in many tissues and cell types.^3,4,5,6 The human GATA-3 gene has been mapped to chromosome 10p14.¹¹ GATA-3 immunoreactivity is frequently seen in urothelial carcinoma with frequencies ranging from 70-99% depending on the study cohort.^7,8,9,10 GATA-3 is a helpful marker aiding in confirming the diagnosis of urothelial carcinomas when the GATA-3 antibody is used in combination with appropriate non-IHC staining and with other appropriate markers in an IHC panel.

Specifications

Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

1. Sellheyer K, Krahl D. Expression pattern of GATA-3 in embryonic and fetal human skin suggests a role in epidermal and follicular morphogenesis. J Cutan Pathol. 2010 Mar;37(3):357-61.
2. Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z. GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors. Am J Surg Pathol. 2014 Jan;38(1):13-22.
3. Higgins JP, et al. Placental S100 (S100P) and GATA3: markers for transitional epithelium and urothelial carcinoma discovered by complementary DNA microarray. Am J Surg Pathol. 2007; 31:673-80.
4. Liu, H, et al. Immunohistochemical evaluation of GATA3 expression in tumors and normal tissues: a useful immunomarker for breast and urothelial carcinomas. Am J Clin Pathol. 2012; 138:57-64.
5. Joulin V, et al. A T-cell specific TCR delta DNA binding protein is a member of the human GATA family. EMBO J. 1991; 10: 1809-16.
6. Labastie M, et al. Structure and expression of the human GATA3 gene. Genomics; 21:1-6.
7. Leivo MZ, Elson PJ, Tacha DE, Delahunt B, Hansel DE. A combination of p40, GATA-3 and uroplakin II shows utility in the diagnosis and prognosis of muscle-invasive urothelial carcinoma. Pathology. 2016 Oct;48(6):543-9.
8. Chang A, Amin A, Gabrielson E, Illei P, Roden RB, Sharma R, Epstein JI. Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung. Am J Surg Pathol. 2012 Oct;36(10):1472-6.
9. Mohammed KH, Siddiqui MT, Cohen C. GATA3 immunohistochemical expression in invasive urothelial carcinoma. Urol Oncol. 2016 Oct;34(10):432.e9-432.e13.
10. Yoo D, Min KW, Pyo JS, Kim NY. Diagnostic and Prognostic Roles of GATA3 Immunohistochemistry in Urothelial Carcinoma. Medicina (Kaunas). 2023 Aug 11;59(8):1452.
11. https://www.genecards.org/cgi-bin/carddisp.pl?gene=GATA3