CytoFISH Multiplex FISH Probe

Product Description

CytoFISH Multiplex probe is a cocktail of 4 individually fluorescently labeled probes: Copy Control 10 (green), Copy Control 7 (orange), Copy Control 3 (aqua), and 5p15.2 (red). Amplification at the 5p15.2 locus is strongly linked to high-grade, advanced-stage bladder tumors and rapid tumor cell proliferation in urinary cancer (1). Cytogenetic analysis demonstrated that 5p might be involved in translocations and/or formation of isochromosomes in a substantial number of bladder tumors (2). Gains at Chromosomes 3, 7, and 10 are seen more frequently in invasive urothelial tumors (3).

Specifications

1.TRIO Amplification and Abundant mRNA Expression Is Associated with Invasive Tumor Growth and Rapid Tumor Cell Proliferation in Urinary Bladder Cancer. Zheng, et al. Am J Pathol. 2004 Jul;165(1):63-9
2. Review of Chromosome Studies in Urological Tumors. II. Cytogenetics and Molecular Genetics of Bladder Cancer. Sandberg AA, Berger CS. J Urol. 1994 Mar;151(3):545-60
3. Molecular pathogenesis of bladder cancer. Knowles MA. Int J Clin Oncol. 2008 Aug;13(4):287-97
4. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.