CD8

Product Description

CD8 is a cell surface glycoprotein member of the immunoglobulin superfamily. CD8 consists of two chains, alpha and beta, which are expressed as a disulphide-linked alpha/beta heterodimer or as an alpha/alpha homodimer on a subset of T-cells, thymocytes and NK cells.¹⁵ The majority of CD8+ T cells express CD8 as alpha/beta heterodimer. CD8 functions as a co-receptor in concert with TCR for binding the MHC class I/peptide complex. The HIV-2 envelope glycoprotein binds CD8 alpha chain (but not beta chain). MHC class I restricted receptor; binds to nonpolymorphic region of class I molecules and may increase avidity of interactions between cytotoxic T-cell and target cell during antigen specific activation.^15-17 Some T-cell lymphomas, such as mycosis fungoides, may aberrantly express CD8. CD8 may be used to aid in the identification of a subset of normal T-cells and sub-classification of T-cell lymphoma.^16,17

Specifications

1. Barth TF, et al. Virchows Arch. 2000 Apr; 436(4):357-64.
2. Williamson SL, et al. Am J Pathol. 1998 Jun; 152 (6):1421-6.
3. Abramov D, et al. Haematologica. 2013 May 28. [Epub ahead of print] 4. Hodak E, et al. Am Acad Dermatol. 2006 Aug; 55(2):276-84.
5. Tirumalae R, Panjwani PK. Indian J Dermatol. 2012 Nov; 57(6):424-7.
6. Izban KF, et al. Mod Pathol. 1998; 11(10):978-82.