CD30 Ki-1 antibody is expressed in mononuclear Hodgkin’s and multinucleated Reed-Sternberg cells in Hodgkin’s disease, in tumor cells of a majority of anaplastic large cell lymphomas, in a varying proportion of activated T and B cells, and by embryonal carcinomas. It aids in distinguishing large cell lymphomas derived from activated lymphoid cells, from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells, or from anaplastic carcinomas. It has been shown that CD30 with CD15 may be used to differentiate between anaplastic large cell lymphoma and Hodgkin’s disease (Reed-Sternberg cells).
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