CD247 is a 16-kDa T-cell surface glycoprotein, also known as CD3 zeta-chain or T-cell antigen receptor (TCR)-Z, which constitutes part of the TCR complex. CD247 is a crucial molecule in the structure, expression, and function of TCR and natural killer (NK) cell-activating receptors. When CD247 is downregulated, T-cell responsiveness and proliferative capacity will be altered (1).
CD247 staining was observed in various proportions of tumor cells and tumor-infiltrating lymphocytes (TILs), localized in the cytoplasm. Reduced levels of CD247 in both TILs and peripheral blood lymphocytes are associated with many cancers including gastric carcinoma, head and neck cancer, B-cell lymphoma, and renal carcinoma. CD247 plays an important role in signal transduction and may be used as a biomarker for evaluating the status of the immune system (2,3). Studies suggest that CD247 may be a therapeutic target for ovarian cancer treatment (1).