CD8

Product Description

CD8 rabbit antibody is a T-cell subset found in cortical thymocytes, T-cells and natural killer (NK) cells. CD8 rabbit antibody stains cortical thymocytes (70-80%), T-cells (25-35% of mature peripheral T-cells) and NK cells (30%). Studies have shown that CD8 is expressed more frequently in non-common type anaplastic lymphoma kinase positive anaplastic large cell lymphomas compared to the common form. The CD4:CD8 ratio may be helpful in distinguishing mycosis fungoides from its inflammatory mimics or as an aid in determining clinical outcome in cervical carcinoma. CD8 may be used in panels with CD3, CD4, CD57 and TIA-1.

Specifications

1. Barth TF, et al. Virchows Arch. 2000 Apr; 436(4):357-64.
2. Williamson SL, et al. Am J Pathol. 1998 Jun; 152 (6):1421-6.
3. Abramov D, et al. Haematologica. 2013 May 28. [Epub ahead of print] 4. Hodak E, et al. Am Acad Dermatol. 2006 Aug; 55(2):276-84.
5. Tirumalae R, Panjwani PK. Indian J Dermatol. 2012 Nov; 57(6):424-7.
6. Izban KF, et al. Mod Pathol. 1998; 11(10):978-82.