HHV-8 [13B10]

Product Description

Human herpesvirus 8 (HHV-8) also known as Kaposi sarcoma-associated herpesvirus (KSHV), encodes a latent nuclear antigen which is the product of the viral gene ORF73.¹ The protein is expressed predominantly during viral latency and appears to play a role in viral integration into the host genome.¹ HHV-8 is associated with Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease, in which tumor cells express the latencyassociated nuclear antigen.²

Specifications

1. Patel RM, Goldblum JR, Hsi ED. Immunohistochemical detection of human herpes virus-8 latent nuclear antigen-1 is useful in the diagnosis of Kaposi sarcoma. Mod Pathol. 2004 Apr;17(4):456-60.
2. Broussard G, Damania B. Regulation of KSHV Latency and Lytic Reactivation. Viruses. 2020 Sep 17;12(9):1034.
3. Center for Disease Control Manual. Guide: Safety Management, NO. CDC- 22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
4. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory Workers from Occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.