SATB2 [CL0323]

Product Description

SATB2 (special AT-rich sequence binding 2) is a human DNA-binding protein involved in transcriptional regulation and chromatin remodeling.^15,16 SATB2 protein expression in normal human tissue was found in the epithelium of the lower gastrointestinal tract including appendix, colon and rectum. SATB2 protein expression was also found in non–germinal center lymphoid cells, and the ductal epithelium of the testis and epididymis. In cancer tissues, SATB2 was shown to be almost exclusively expressed in colorectal carcinoma.¹⁷ SATB2 may be useful in distinguishing adenocarcinomas of colorectal origin from those of gastric and pancreatic origin.¹⁸

Specifications

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15. FitzPatrick DR, et al. Identification of SATB2 as the cleft palate gene on 2q32-q33. Hum Mol Genet 2003; 12:2491-2501.
16. Szemes M, et al. Isolation and characterization of SATB2, a novel ATrich DNA binding protein expressed in development- and cell-specific manner in the rat brain. Neurochem Res. 2006 Feb;31(2):237-46.
17. Magnusson K, et al. SATB2 in combination with cytokeratin 20 identifies over 95% of all colorectal carcinomas. Am J Surg Pathol. 2011; 35:937– 48.
18. Berg KB, Schaeffer DF. SATB2 as an immunohistochemical marker for colorectal adenocarcinoma: A concise review of benefits and pitfalls. Arch Pathol Lab Med. 2017 Oct;141(10):1428-1433.