Bcl-6 [LN22]

Product Description

The Bcl-6 gene, originally cloned from a tumor with 3q27 translocation, is commonly expressed in large cell lymphomas. In humans, Bcl-6 encodes for a Kruppel-type zinc finger protein that is believed to be important in germinal center formation. Bcl-6 protein is expressed mainly by follicle center cells and in a few interfollicular T-lymphocytes. Bcl-6 has also been detected in Burkitt’s lymphoma and in nodular lymphocyte predominant Hodgkin’s disease. Bcl-6 is not expressed in hairy cell leukemia, mantle cell or marginal-zone derived lymphomas. This antibody demonstrates strong nuclear reactivity.

Specifications

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