WT1
WT1 is a gene involved in the induction of Wilms’ Tumor. The WT1 gene, located on 11p13, is inactivated in 5 to 10% of sporadic Wilms’ tumors and in nearly 100% of Denys-Drash patients. In normal tissues, WT1 (mRNA) has been observed in human kidney, spleen and gonadal ridge mesoderm. The WT1 gene has also been observed in sertoli cells of testes and in granulosa cells of the ovary. In tumors, WT1 has been demonstrated in Wilms’ tumors and in the majority or mesotheliomas (nuclear and paranuclear staining). WT1 has also been demonstrated in the majority of acute leukemias, but not in cells from chronic myelogenous leukemia. Cytoplasmic staining has been observed in some cases of adenocarcinoma and may represent cross-reactivity with an epitope unrelated to WT1.
| Ordering Information |
Catalog Number |
Volume |
| Concentrate |
CM 258 |
AK, BK, CK |
| Predilute |
PM 258 |
AA |
| intelliPATH™ |
IP 258 |
G10 |
| VP Echelon |
N/A |
N/A |
| A / AK = 0.1 ml |
B / BK = 0.5 ml |
C / CK = 1.0 ml |
G5 = 5.0 ml |
AA = 6.0 ml |
H / G25 = 25 ml |
L = 100 ml |
