Oct-3/4
Oct-3/4 is an 18-kDa POU-domain transcription factor encoded by the POU5F1 gene. The gene which encodes Oct-3/4 maps the human chromosome 6p21.31. Oct-3/4 is involved in regulation of pluripotency during normal development and is detectable in embryonic stem and germ cells. Transcription factors containing the POU homeo domain have been shown to be important regulators of tissue-specific gene expression in lymphoid and pituitary differentiation and in early mammalian development Oct-3 (also known as Oct-4) is a mammalian POU transcription factor expressed by early embryo cells and germ cells. Oct-3/4 is essential for the identity of the pluripotential founder cell population in the mammalian embryo. Studies have shown Oct-3/4 immunohistochemistry is an informative diagnostic tool for pluripotent germ-cell tumors and offers new insights into the histological heterogeneity of this cancer. Studies have demonstrated that Oct-3/4 is a highly specific and sensitive immunohistochemical marker for primary intracranial germinomas and is a sensitive and specific maker for intratubular germ cell neoplasia. The intensity of Oct-3/4 immunostaining has been shown to be significantly better than that of PLAP.
| Ordering Information |
Catalog Number |
Volume |
| Concentrate |
N/A |
N/A |
| Predilute |
PM 313 |
AA |
| intelliPATH™ |
IP 313 |
G10 |
| VP Echelon |
Use Predilute |
|
| A / AK = 0.1 ml |
B / BK = 0.5 ml |
C / CK = 1.0 ml |
G5 = 5.0 ml |
AA = 6.0 ml |
H / G25 = 25 ml |
L = 100 ml |
