CMV is a member of the human herpes virus-5, HHV-5 group and can be transmitted via breast milk, during organ transplantation, sexual activity or blood transfusions. It is estimated that 40-100% of people may be infected with this virus (1,2,4). CMV infections are common causes of morbidity and mortality especially in immune compromised individuals (1-3). The in situ hybridization technique offers an important advantage over immunohistochemistry, as it virtually lacks background, and allows a clean and sharp viewing of the histological preparation.
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2. Cobbs CS, Soroceanu L, Denham S, Zhang W, Kraus MH. Modulation of oncogenic phenotype in human glioma cells by cytomegalovirus IE1-mediated mitogenicity. Cancer Res. 2008 Feb 1;68(3):724-30.
3. Harkins L, Volk AL, Samanta M, Mikolaenko I, Britt WJ, Bland KI, Cobbs CS. Specific localisation of human cytomegalovirus nucleic acids and proteins in human colorectal cancer. Lancet. 2002 Nov 16;360(9345):1557-63.
4. Cobbs CS, Harkins L, Samanta M, Gillespie GY, Bharara S, King PH, Nabors LB, Cobbs CG, Britt WJ. Human cytomegalovirus infection and expression in human malignant glioma. Cancer Res. 2002 Jun 15;62(12):3347-50.