This RNA negative control probe consists of a random set of oligonucleotide sequences with a GC content of 40-70%. It should be used to assess non-specific staining when performing in situ hybridization in FFPE tissues. No positive staining should result with the use of this probe.
1. Wilkinson DG. In Situ Hybridization, A Practical Approach, Oxford University Press (1992) ISBN 0 19 963327 4.
2. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
3. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory Workers from Occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.