PMS2

Product Description

The PMS2 post meiotic segregation increased 2 (PMS2) gene is located on chromosome number 7.¹ PMS2 functions, along with MSH2, MLH1, and MSH6, as part of the DNA mismatch repair (MMR) pathway, are utilized by normal proliferating cells to repair mutations that may occur during DNA replication. The gene product of PMS2 forms a heterodimer with MLH1 that interacts with MSH2 bound to mismatched bases in DNA. Antibodies to PMS2 may be a useful aid for classification of tumors of the gastrointestinal tract, including colorectal cancers.^1,2

Specifications

1. Sordet C, Goetz J, Sibilia J. Contribution of autoantibodies to the diagnosis and nosology of inflammatory muscle disease. Joint Bone Spine. 2006 Dec;73(6):646-54.
2. Peltomäki P. Role of DNA mismatch repair defects in the pathogenesis of human cancer. J Clin Oncol 2003,21:1174-9