The PHLPP1(18q21) Red Copy Control 18 Green probe is designed to detect copy number variations in the 18q21 region on chromosome 18. The PHLPP1 gene encodes a protein phosphatase that regulates cell growth and survival pathways1. It has been stated that PHLPP1 gene aberrations contribute to the deregulation of the AKT and PKC cell growth and survival pathway in colorectal cancer1. PHPPL1 gene expression exhibits tumor suppressor properties in colon cancer1. Furthermore, PHLPP1 may serve as a therapeutic target that inhibits prostate cancer progression through mTORC2 antagonism2. Preliminary studies also suggest a correlation between PHLPP1 and
PTEN gene aberrations related to prostate cancer metastasis 2.