p53 homologue p63 encodes for different isotypes able to either transactivate p53 reporter genes (TAp63) or act as p53-dominant-negatives. Studies have shown that p63 [4a4] antibody detection by IHC has clinical utility in the evaluation of lung, prostate, cervical and other types of cancer in formalin fixed, paraffin-embedded (FFPE) human tissues. A cocktail of p63 and TRIM29 can also be utilized for lung SqCC and studies have shown that when p63 and/or TRIM29 is expressed in lung SqCC, a 95.4% sensitivity and 100% specificity was achieved, if Napsin A and TTF-1 were both negative in the same case.
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