HHV-8 [13B10]

Product Description

Human herpesvirus 8 (HHV-8) also known as Kaposi sarcoma-associated herpesvirus (KSHV), encodes a latent nuclear antigen which is the product of the viral gene ORF73.1 The protein is expressed predominantly during viral latency and appears to play a role in viral integration into the host genome.1 HHV-8 is associated with Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease, in which tumor cells express the latencyassociated nuclear antigen.2

Specifications

1. Patel RM, Goldblum JR, Hsi ED. Immunohistochemical detection of human herpes virus-8 latent nuclear antigen-1 is useful in the diagnosis of Kaposi sarcoma. Mod Pathol. 2004 Apr;17(4):456-60.
2. Broussard G, Damania B. Regulation of KSHV Latency and Lytic Reactivation. Viruses. 2020 Sep 17;12(9):1034.
3. Center for Disease Control Manual. Guide: Safety Management, NO. CDC- 22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
4. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory Workers from Occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.