FGFR1 (8p11) Red + Copy Control 8 Green FISH Probe

Product Description

The FGFR1(8p11) Red Copy Control 8 Green probe is designed to detect copy number variations of the 8p11 region on chromosome 8. The fibroblast growth factor receptor (FGFR1) gene encodes a tyrosine kinase receptor and is responsible for cell growth and differentiation1. FGFR1 gene aberrations have been associated with many types of cancers such as breast, prostate, kidney and lung cancers 1, 2, 3. Specifically, the amplification of the FGFR1 gene is believed to play a role in breast cancer carcinogenesis 2. Moreover, it has been stated that FGFR1 gene expression correlates with an increased Gleason score in prostate cancer3. The listed pathogenic features make FGFR1 a strong prognostic marker and viable therapeutic target in multiple cancer types.

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