This antibody reacts with type IV collagen, which is the major constituent of the basement membranes. Collagen IV antibody stains the basement membranes in a variety of tissues including kidney, muscle, lymph nodes, lung, tendon and spleen. Collagen IV has been shown to be useful in differentiating microinvasive from in situ ductal carcinomas of the breast. Other collagen IV studies include use in pancreatic adenocarcinoma and chronic pancreatitis, nephrosclerosis and other kidney diseases, oral squamous cell carcinoma, laryngeal cancers, ovarian cancers and cervical cancers.
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