CD31 (PECAM-1)

Product Description

CD31 recognizes a 100kDA glycoprotein in endothelial cells and 130kD in platelets. It reacts weakly with mantle zone B-cells, peripheral T-cells, and neutrophils.¹⁵ CD31 can detect vascular endothelium associated antigen and has been used as a marker for benign and malignant human vascular disorders, myeloid leukemia infiltrates and megakaryocytes in normal bone marrow.^15-17 CD31 can be used as a marker for myeloid progenitor cells that recognize different subsets of myeloid leukemia infiltrates (granular sarcomas).¹⁸

Specifications

1. Govender D, Harilal P, Dada M, Chetty R. CD31 (JC70) expression in plasma cells: an immunohistochemical analysis of reactive and neoplastic plasma cells. J Clin Pathol 1997 Jun;50(6):490-3.
2. Rongioletti F et al. Tumor vascularity as a prognostic indicator in intermediatethickness (0.76-4 mm) cutaneous melanoma. A quantitative assay. Am J Dermatopathol 1996 Oct;18(5):474-7.
3. Engel CJ, Bennett ST et al.. Tumor angiogenesis predicts recurrence in invasive colorectal cancer when controlled for Dukes staging. Am J Surg Pathol 1996 Oct;20 (10):1260-5.
4. Russell Jones R et al. Staining for CD31 and CD34 in Kaposi sarcoma. Virchows Arch 1996 Jul;428(4-5):217-21.
5. Poblet E et al. Different immunoreactivity of endothelial markers in well and poorly differentiated areas of angiosarcomas. J Clin Pathol 1995 Nov;48(11):1011-6.
6. Hudock J, Chatten J, Miettinen M. Immunohistochemical evaluation of myeloid leukemia infiltrates (granulocytic sarcomas) in formaldehyde-fixed, paraffin-embedded tissue. Am J Clin Pathol. 1994 Jul;102(1):55-60.
7. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
8. National Committee for Clinical Laboratory Standards(NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood an