CD21 antibody has been shown to label follicular dendritic cells, as a means of illustrating the phenomenon of follicular colonization in marginal zone lymphoma. Follicular dendritic cell markers such as SR-100, CD21 or CD35 may be used for the differential diagnosis in tonsillar masses. CD21 has also been used in proving cell lineage in some rare follicular dendritic cell tumors. CD21 has been shown to be a reliable marker of follicular dendritic cells in angioimmunoblastic T-cell lymphomas.
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