CD117/c-kit antibody is a member of Tyrosine Kinase kDa (-3) Receptor (TKR) family and is highly homologous to receptor PDGF and CSF-1. This antibody recognizes the extracellular domain and is expressed by a variety of normal and abnormal cell types. In abnormal cells, CD117 has been shown to label testicular germ cells, endometrial carcinomas, papillary and follicular thyroid carcinomas, small cell carcinomas, melanomas and ovarian epithelial carcinomas. It has also been shown to be an effective marker for mast cell disorders, gastrointestinal stromal tumors and immunotyping of blasts in human bone marrow.
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