CD103 (RM)
$237.00 – $622.00
Description
Product Description
The Biocare CD103 [EP206] antibody detects the integrin subunit CD103, a cell surface antigen characteristically expressed in hairy cell leukemia (HCL), a Bcell lymphoproliferative disorder.15,17 CD103 [EP206] has demonstrated reactivity in formalin-fixed paraffinembedded (FFPE) tissue, eliminating the need for flow cytometry or frozen section IHC and making it a valuable component of an IHC panel for HCL diagnosis.15 Other antibodies commonly used in conjunction with CD103 for HCL detection include CD25, TIA-1, DBA44, and CD11c.16,17 Additionally, intraepithelial CD8⁺ tumor-infiltrating lymphocytes (TILs) expressing CD103 have been strongly associated with patient survival in high-grade serous ovarian cancer (HGSC).18
Specifications
Specifications
| Intended Use | |
|---|---|
| Format | |
| Volume | |
| Source | |
| Clone | |
| Isotype | |
| Antigen | A synthetic peptide corresponding to the residues of human CD103 protein |
| Localization | |
| Positive Control |
Datasheets & SDS
| Download CE Marked IVD Datasheet |
| Download IVD Datasheet Without CE Mark |
| Download RUO Data Sheet |
| Download SDS Sheet |
Browse more documents for this product (IFUs, datasheets, translations, SDS, and more).
References
1. Morgan EA, et al. Immunohistochemical detection of hairy cell leukemia in paraffin sections using a highly effective CD103 rabbit monoclonal antibody. Am J Clin Pathol. 2013 Feb; 139(2):220-30.
2. Dong HY, et al. Immunophenotypic analysis of CD103+ B-lymphoproliferative disorders: hairy cell leukemia and its mimics. Am J Clin Pathol. 2009 Apr; 131(4):586 -95.
3. Mori N, et al. TIA-1 expression in hairy cell leukemia. Mod Pathol. 2004 Jul; 17 (7):840-6.
4. Webb JR, et al. Tumor-infiltrating lymphocytes expressing the tissue resident memory marker CD103 are associated with increased survival in high-grade serous ovarian cancer. Clin Cancer Res. 2014 Jan 15; 20(2):434-44.
5. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
6. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory Workers from Occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.
