ALK (2p23.2) Break Apart Orange/Green

Product Description

The ALK (2p23.2) Break Apart FISH Probe is designed to detect the rearrangement of the ALK gene located on 2p23. The ALK gene can fuse with one of 20 known ALK gene rearrangement partners, the most common being t(2;5)(p23;q35) (1). The resultant fusion proteins generated from ALK gene rearrangement plays a vital role in driving the pathogenesis of several different types of cancer, such as non-small cell lung cancer and anaplastic large cell lymphoma (2).

Specifications

1. Pearson, Joel D., Jason K. H. Lee, Julinor T. C. Bacani, Raymond Lai, and Robert J. Ingham. “NPM-ALK: The Prototypic Member of a Family of Oncogenic Fusion Tyrosine Kinases.” Journal of Signal Transduction: 1-14.
2. Iacono, D., R. Chiari, G. Metro, C. Bennati, G. Bellezza, C. Cenci, B. Ricciuti B, A. Sidoni, S. Baglivo, V. Minotti, and L. Crinò. “Future Options for ALK-positive Non-small Cell Lung Cancer.” Lung Cancer 87.3 (2014): 211–219.
3. Clinical and Laboratory Standards Institute (CLSI). Protection of Laboratory workers from occupationally Acquired Infections; Approved Guideline-Fourth Edition CLSI document M29-A4 Wayne, PA 2014.