CD30

Product Description

The CD30 antigen, initially designated Ki-1, recognizes a single chain transmembrane glycoprotein that has been demonstrated to be homologous to members of the nerve growth factor receptor superfamily. The mature 120 kDa molecule is formed from 90 kDa precursor molecules processed in the Golgi system.¹⁶ The Ki-1 (CD30) antigen is expressed in mononuclear Hodgkin’s and multinucleated Reed-Sternberg cells in Hodgkin’s disease.^16-18 It is expressed by the tumor cells of a majority of anaplastic large cell lymphomas, and by a varying proportion of activated T and B cells.^18,19 It distinguishes large cell lymphomas derived from activated lymphoid cells, from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells, or from anaplastic carcinomas.^15,16,19 CD30 may be used to differentiate between anaplastic large cell lymphoma and Hodgkin’s disease (ReedSternberg cells).^15-19

Specifications

1. Tilly H, et al. Blood. 1997 Nov; 90(9):3727-34.
2. Filippa DA, et al. Blood. 1996 Apr; 87(7):2905-17.
3. Clavio M, et al. Leuk Lymphoma. 1996 Jul; 22(3-4):319-27.
4. Pallesen G, Hamilton-Dutoit SJ. Am J Pathol. 1988 Dec; 133(3):446-50.