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TIA-1 antibody (T-cell intracytoplasmic antigen) is expressed in lymphocytes processing cytolytic potential. Studies show that 60 to 70% of anaplastic large cell lymphoma reacts with TIA-1. Studies also indicate that TIA-1 reacts with most large granular lymphocytic leukemias, hepatosplenic T-cell lymphomas, intestinal T-cell lymphomas, NK-like T-cell lymphomas, NK cell lymphomas, nasal T/NK-cell lymphomas, subcutaneous T-cell lymphomas and pulmonary angiocentric lymphomas of T-or NK-phenotype. All B-cell lymphomas, Hodgkin’s and lymphoblastic leukemias were negative for TIA-1.
TIA-1 (T-cell intracytoplasmic antigen)
Anaplastic large cell lymphoma or tonsil
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2. Kanavaros P et al. Cytotoxic protein expression in non-Hodgkin’s lymphomas and Hodgkin’s disease. Anticancer Res 1999 Mar-Apr;19(2A):1209-16.
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4. National Committee for Clinical Laboratory Standards (NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991;7(9). Order code M29-P.