In normal epithelia, HMW Cytokeratins (CK5 and CK14) stain basal epithelia in the prostate gland.p63 is detected in prostate basal epithelial nuclei in normal prostate, however, is negative in malignant tumors of the prostate gland. Thus p63 is useful as a differential marker for benign and malignant tumors of the prostate gland and can be useful as a negative marker. Prostate – 2X can be used in combination with an additional antibody to generate a PIN-4 combination (see technical notes).
Datasheets & SDS
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3. Yang A, et al. p63, a p53 homolog at 3q27–29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell. 1998 Sep;2 (3):305-16.
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9. Tokar EJ, et al. Stem/progenitor and intermediate cell types and the origin of human prostate cancer. Differentiation. 2005 Dec;73(9-10):463-73.
10. Collins AT, et al. Identification and isolation of human prostate epithelial stem cells based on alpha(2)beta(1)-integrin expression. J Cell Sci. 2001 Nov;114(Pt 21):3865-72.
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