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Hairy Cell Leukemia [DBA.44]
$210.00 – $420.00
Description
Product Description
Hairy Cell Leukemia is a rare hematological malignancy in which B-cell lymphocytes are produced in excessive quantities. Hairy Cell Leukemia is characterized by small lymphocytes bearing fine hair-like cytoplasmic projections with infiltration of reticuloendothelial organs such as lymphoid organs and bone marrow.15,16 This mouse monoclonal antibody, also referred to as DBA.44, may be used in immunohistochemistry (IHC) testing using bone marrow biopsies to identify Hairy Cell Leukemia over low grade B-cell lymphomas.17 DBA.44 shows a high and consistent reaction with tissue infiltrates of Hairy Cell Leukemia, with a detection rate of 96%.18
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Specifications
Specifications
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Datasheet & SDS
References
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9. College of American Pathologists (CAP) Certification Program for Immunohistochemistry. Northfield IL. Http://www.cap.org (800) 323- 4040.
10. O’Leary TJ, Edmonds P, Floyd AD, Mesa-Tejada R, Robinowitz M, Takes PA, Taylor CR. Quality assurance for immunocytochemistry; Proposed guideline. MM4-P. National Committee for Clinical Laboratory Standards (NCCLS). Wayne, PA. 1997;1-46.
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13. Omata M, Liew CT, Ashcavai M, Peters RL. Nonimmunologic binding of horseradish peroxidase to hepatitis B surface antigen: a possible source of error in immunohistochemistry. AmJ Clin Path 1980; 73:626.
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15. Lipták J, Piukovics K, Borbényi Z, et al. A comprehensive immunophenotypic marker analysis of hairy cell leukemia in paraffinembedded bone marrow trephine biopsies–a tissue microarray study. Pathol Oncol Res. 2015 Jan;21(1):203-11.
16. Getta BM, Park JH, Tallman MS. Hairy cell leukemia: Past, present and future. Best Pract Res Clin Haematol. 2015 Dec;28(4):269-72.
17. Kreitman RJ. Hairy cell leukemia: present and future directions. Leuk Lymphoma. 2019;60(12):2869-2879.
18. Sherman MJ, Hanson CA, Hoyer JD. An assessment of the usefulness of immunohistochemical stains in the diagnosis of hairy cell leukemia. Am J Clin Pathol. 2011 Sep;136(3):390-9.
