Biocare Medical is proud to announce the launch of a mouse monoclonal PAX8 antibody. Unlike current existing PAX8 polyclonals, the PAX8 mouse clone [BC12] has been designed for specific epitope targeting. The monoclonal PAX8 does not stain B-cells, cells of pancreatic origin or neuroendocrine cells of the stomach or colon. This antibody also has lower nonspecific background staining as well as lot to lot consistency.

PAX8 is a member of the paired box (PAX) family of transcription factors, which plays critical roles during fetal development and cancer growth. Normal PAX8 expression is required for kidney cell differentiation and thyroid development. Studies show that expression of the PAX8 gene is also found in 89% of analyzed tumor samples, including a high percentage of renal cell carcinomas (including clear cell, chromophobe and papillary carcinoma) and ovarian cancers.

The PAX8 monoclonal antibody can also be paired with additional antibodies to increase sensitivity or for tumor of unknown origin identification. PAX8, in combination with Renal Cell Carcinoma Marker (RCCm), stains over 90% of primary tumors and 85% of metastatic renal cell carcinomas. For identification of tumors of unknown origin, PAX8 can be used in a panel with a CD10 antibody.

This monoclonal PAX8 antibody provides superior diagnosis compared to existing PAX8 polyclonals.

About Biocare Medical
Biocare Medical LLC is an innovator in developing and supplying world class automated immunohistochemistry instrumentation, and the full range of reagents for IHC lab testing. Biocare is the market leader in simultaneous Multiplex IHC and antibody development which solves difficult clinical problems and accelerates turnaround time. The company’s customers include clinical histology laboratories, pharmaceutical companies, CROs, and biotechnology companies, as well as academic, government, military, and other non-profit laboratories. Biocare Medical offers an expanding portfolio of integrated products to address the rapidly growing cancer and infectious disease diagnostic and research markets using tissue immunostaining and in situ hybridization methods. Biocare Medical is headquartered and has manufacturing facilities in Concord, Calif., and has a global distribution network.

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