Studies have shown Cytokeratin 5/6 antibody reacts with human epidermis and non-keratinizing epithelium. It has also been shown to react with cytokeratin 6, weakly with cytokeratin 4, and does not react with cytokeratins 1, 7, 8, 10, 13, 14, 18 and 19. CK5/6 has been shown to express in the vast majority of squamous cell carcinoma, basal cell carcinomas, thymomas, salivary gland tumors, and mesothelioma. It rarely reacts with pulmonary adenocarcinomas.
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