This antibody reacts with a human intermediate filament protein of 50 kDa, known as Cytokeratin 14 antibody. Studies have shown that it can be used to distinguish stratified epithelial cells from simple epithelial cells. In neoplastic cells, CK14 may be a useful marker in the differential diagnosis of squamous cell carcinoma from other epithelial tumors. Recent studies also indicate that CK14 expression in breast cancer corresponded with poor clinical outcome and that CK14 may have diagnostic value in the sub-classification of NSCLC.
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