The Biocare S100P antibody recognizes placental S100 binding protein, a member of the S100 family of proteins originally identified in the placenta and later associated with cancer.15,17 Members of the S100 protein family function as extracellular and/or intracellular regulators of diverse cellular processes and are implicated in various human pathologies. Functional studies indicate that S100P […]
Approximately 12,000 men and women in the United States are diagnosed with gallbladder cancer annually, leading to an annual estimated 4,000 deaths.1 Gallbladder and other biliary cancers are comparatively rare in the United States, with about 0.7% of new cancer cases classified as gallbladder, contributing approximately 0.6% of cancer deaths yearly.1 Worldwide, gallbladder and other […]
Distinguishing between invasive urothelial carcinoma (UC) from other genitourinary malignancies, such as prostatic and renal carcinomas, can be difficult. Several new markers such as GATA binding protein 3 (GATA-3), S100P, and uroplakin III have been developed for this differentiation (1-7). More recently uroplakin II has been introduced (1-7). GATA-3 is a transcription factor and belongs […]
Lung cancers are the third most diagnosed cancer in the United States, with about 13.5% of new cancer cases classified as lung, contributing 27.2% of cancer deaths yearly. As of 2011, there were approximately 402,000 people living with lung cancer in the United States. Those diagnosed with lung cancer have a 5 year survival rates […]
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Uroplakin III is present in the urothelial surface membrane of human renal pelvis, ureter, bladder and urethra. Uroplakin III [BC17] demonstrated a higher sensitivity compared with [AU1] on urothelial transitional cell carcinomas, in in-house studies. [BC17] staining was negative in all normal and neoplastic tissues except for bladder; hence it is highly specific to uroepithelial […]
A New and Innovative Antibody p16 INK4a [BC42]: An IHC Comparative Analysis with Clone [E6H4] NSH 2019 Download Rodent Multi-Species Multiplex Immunohistochemistry Using Digoxigenin and Polymer Detection Methods in Mouse Tissues AACR 2018 Download A Multiplex Immunohistochemistry Evaluation of Immune Checkpoint Receptors and Mismatch Repair Proteins in Colorectal Carcinoma AACR 2018 Download Sequential Multiplex Immunofluorescence […]
The HMB45 clone reacts with a neuraminidase-sensitive oligosaccharide side chain of a glycoconjugate present in immature melanosomes. The HMB45-reactive antigen is present in cutaneous melanocytes, prenatal and infantile retinal pigment epithelium and melanoma cells. It is also thought to be oncofetal in nature. This antibody has been shown to label the majority of melanomas. The […]
GATA-3 (GATA binding protein 3) is a member of the GATA family of transcription factors. This 50 kDa nuclear protein regulates the development and is expressed in specific cell types within a variety of tissues.1,2 GATA-3 is a zinc finger transcription factor and plays an important role in promoting and directing cell proliferation, development, and […]
