Ki-67 + Caspase-3 can provide information on cell death vs. cell proliferation in the same tissue section. The Ki-67 nuclear antigen is associated with cell proliferation and is used to grade proliferation rates of tumors. Ki-67 is found throughout the cell cycle that includes the G1, S, G2, and M phases; but not the G0 […]
The Biocare Caspase-3 (Cleaved) antibody detects the large fragment (17/19 kDa) of activated caspase-3 that results from cleavage adjacent to Asp175. Caspase-3 is a cysteinyl-aspartic acid protease (caspase) that plays a key role in the execution phase of apoptosis. Activation of caspase-3 requires proteolytic processing of its inactive zymogen into active p17 and p12 subunits. […]
What Tissues Are You Working With?
Pan Lymphoma Cocktail (LCA + CD20 + CD3 + CD43) are specific leukocyte markers used in the identification and assessment of lymphoid neoplasms. This combination of antibodies offers a marker for the identification of a variety of leukocytes. CD45 also known as leucocyte common antigen (LCA), is expressed on hematopoietic cell lines, but absent on […]
Cytokeratin 18 (CK18) is a 45 kDa acidic intermediate filament protein. It is normally coexpressed with cytokeratin 8 and is found in most simple ductal and glandular epithelia.15 The antibody reacts with a wide variety of neoplastic tissues such as gastrointestinal tract, lung, and breast tumors;16-18 whereas tumor cells of nonepithelial origin such as glioma, […]
