CDX2 is a homeobox gene that encodes an intestine-specific transcription factor and is expressed in the nuclei of epithelial cells of the intestine, from duodenum to rectum. The CDX2 protein is expressed in primary and metastatic colorectal carcinomas (1,2). It has also been identified in primary ovarian mucinous tumors and metastatic mucinous carcinomas involving the […]
The Biocare CDX2 antibody detects CDX2, a homeobox gene–encoded, intestine-specific transcription factor.15 CDX2 is useful in establishing the gastrointestinal origin of metastatic adenocarcinomas and carcinoids and can aid in distinguishing metastatic colorectal adenocarcinoma from tumors of unknown origin.15-21 Studies have shown that CDX2 to be more specific and sensitive than villin or CK20.15,19,20 CDX2 expression […]
CDX2 is a homeobox gene that encodes an intestine-specific transcription factor (1). CDX2 has been useful to establish gastrointestinal origin of metastatic adenocarcinomas and carcinoids and can be especially useful in distinguishing metastatic colorectal adenocarcinoma from tumors of unknown origin (1-7). CDX2 has been shown to be more specific and more sensitive than villin or […]
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Studies have shown CDH17 to be a highly specific IHC marker for colon and stomach adenocarcinomas with improved sensitivity when compared to CK20 & CDX2. Metastatic carcinoma can present diagnostic challenges within the clinical pathology setting1. Historically, a panel consisting of CK7, CK20, and CDX2 has been relied upon to assess gastrointestinal (GI) tumors of […]
Abstract The objective of this study is to examine the efficiency and effectiveness of heat induced epitope retrieval (HIER) when performed on a fully automated instrument using single-sided application of a heating element and topical dispense of retrieval buffer solution, commonly referred to as online retrieval, in comparison to offline HIER via the conventional pressure […]
Increased Staining Consistency and Clarity on the ONCORE Pro X for Multiplex Staining Download pdf Clone Wars – CDX2 – Comparative Analysis Download pdf Understanding FISH vs NGS Capabilities Download pdf Let’s Get Clinical: Understanding Mismatch Repair and Microsatellite Instability Download pdf FISH and Cytogenetic Analysis: Probing for CLL and MDS Download pdf Probing Questions: […]
What Tissues Are You Working With?
Approximately 150,000 men and women in the United States are diagnosed with colorectal cancer annually, leading to an annual estimated 51,000 deaths.1 Colorectal cancers are the third-most common in the United States (excluding skin cancer), with about 8.1% of new cancer cases diagnosed, contributing to approximately 8.3% of cancer deaths yearly.1 Worldwide, colorectal cancers are […]
