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WT1 is a protein involved in the induction of Wilms’ Tumor. The WT1 gene, located on 11p13, is inactivated in 5 to 10% of sporadic Wilms’ tumors and in nearly 100% of Denys-Drash patients. In normal tissues, WT1 (mRNA) has been observed in human kidney, spleen and gonadal ridge mesoderm. The WT1 antibody gene has also been observed in Sertoli cells of testes and in granulosa cells of the ovary. In tumors, WT1 has been demonstrated in Wilms’ tumors and in the majority or mesotheliomas. A study indicates WT1 may be a useful tool in distinguishing schwannoma from fibroblastic meningioma.3

Intended Use


Species Reactivity



Mouse Monoclonal


BC.6F-H2, Biocare Clone


IgG1 /kappa


Wilms’ tumor, mesothelioma


Nuclear, paranuclear and, in some cases, cytoplasmic

Positive Control

Wilms’ tumor, mesothelioma, or normal kidney

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Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

1. Ordonez NG. The immunohistochemical diagnosis of mesothelioma: a comparative study of epithelioid mesothelioma and lung adenocarcinoma. Am J Surg Pathol. 2003 Aug;27(8):1031-51.
2. Center for Disease Control Manual. Guide: Safety Management, NO. CDC-22, Atlanta, GA. April 30, 1976 “Decontamination of Laboratory Sink Drains to Remove Azide Salts.”
3. National Committee for Clinical Laboratory Standards (NCCLS). Protection of laboratory workers from infectious diseases transmitted by blood and tissue; proposed guideline. Villanova, PA 1991;7(9). Order code M29-P.


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