S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. The S100 Protein Cocktail antibody stains melanocytes, schwannomas, peripheral neural tissue, astrocytes, benign and malignant melanomas and their metastases. S100 protein is also expressed in the antigen presenting cells such as the Langerhan’s cells in skin and interdigitating reticulum cells in the paracortex of lymph nodes. S100 protein is highly soluble and may be eluted from frozen tissue during staining. The S100 monoclonal cocktail is potentially more sensitive than other S100 single clone antibodies and may be an excellent pan-melanoma marker.
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